Updated on February 22, 2024
9 min read

7 Best Hydroxyapatite Toothpaste Brands

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7 Best Hydroxyapatite Toothpaste Brands 

Your dentist can provide prescription-strength hydroxyapatite with a more significant concentration of hydroxyapatite. But unless your teeth are at high risk, you may consider an over-the-counter (OTC) option.

Some types of hydroxyapatite contain the nanocrystal form. They are usually advertised as ‘nanohydroxyapatite remineralizing toothpaste.’ 

Others may include a formula that is blended with zinc. There are even options that feature extra-mild aromas for young children.

Here are some effective HAp toothpaste brands to choose from:

1. Boka Nano-Hydroxyapatite Toothpaste (use code NewMouth for 15% off)

Boka Ela Mint Toothpaste

Boka’s Nano Toothpastes trade fluoride for nano-hydroxyapatite (n-Ha). They combine hydroxyapatite with other ingredients to help remineralize and protect teeth. The toothpaste comes in different flavors, such as mint, coco ginger, and lemon lavender.

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2. RiseWell 

RiseWell Toothpaste

RiseWell Toothpaste is a fluoride-free toothpaste that contains naturally-derived hydroxyapatite. It’s also free from parabens, harsh foaming agents, and sulfates. This makes it an excellent choice for strengthening and restoring your tooth enamel.

3. Davids Nano Hydroxyapatite Natural Toothpaste

Davids Nano Hydroxyapatite Natural Toothpaste

Davids’ nano-hydroxyapatite toothpaste is another great choice. It contains nano-hydroxyapatite (n-HA) to repair sensitive teeth and remineralize enamel. 

4. Apagard

Apagard Toothpaste

Apagard is a toothpaste brand from Japan. The Apagard Premio toothpaste is the premium type that has a higher nano-hydroxyapatite concentration. It’s designed to remineralize subsurface demineralized areas for healthier teeth.

5. Dr. Brite

Dr. Brite hydroxyapatite toothpaste

Dr. Brite offers various hydroxyapatite toothpastes. You can choose a toothpaste according to your concern, such as whiter teeth, healthier gums, anti-plaque, and sensitivity relief.

6. Bite

Bite Toothpaste Bits

Bite toothpaste bits differ from your normal toothpaste. This toothpaste comes in tablets, so you must chew them before brushing. This product contains nano-hydroxyapatite to help remineralize your teeth and protect them from cavities.

7. Ollie Hydroxyapatite Toothpaste

Ollie Hydroxyapatite Toothpaste

Ollie’s toothpaste helps fight cavities because it has hydroxyapatite, fluoride, and xylitol. It’s a great option for someone with sensitive teeth because it contains potassium nitrate. Ollie says their toothpaste also has a light mint flavor, perfect for freshening breath without making your mouth burn.

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What is Hydroxyapatite?

Hydroxyapatite (HAp) is a type of calcium that makes up 97 percent of your tooth enamel and 70 percent of the dentin in teeth.

Hydroxyapatite makes up 60% of your bones. It’s used in osteopathic research to help strengthen bone and for restorative restorations and preventive materials. 

The high hydroxyapatite concentration in tooth enamel is the reason it is so robust. It prevents tooth decay, even though acids are constantly attacking our teeth.

As you eat, drink, and live, your teeth constantly undergo demineralization and remineralization. 

What is Hydroxyapatite Toothpaste?

Toothpaste or mouthwashes with fluoride or hydroxyapatite help with the remineralization process. Hydroxyapatite helps strengthen tooth enamel and protect them from decay.

Hydroxyapatite toothpaste is becoming increasingly popular as an alternative to fluoride-based toothpaste. Toothpaste containing hydroxyapatite can create a barrier on your tooth surfaces. This barrier protects teeth against the sugars and acids that wear away at your teeth.

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Is Hydroxyapatite Toothpaste Safe?

Hydroxyapatite toothpaste is safe and beneficial for enamel. Since hydroxyapatite can be naturally found in our bodies, it’s non-toxic. It’s ideal for children, pregnant women, and those with sensitive teeth.

Hydroxyapatite is also biocompatible. This means the body won’t reject it, and it will rarely cause irritation or allergic reactions. It’s also non-abrasive, so it won’t damage your enamel.

A 2019 lab study suggested that hydroxyapatite toothpaste could be a helpful dental product for people at significant risk of developing cavities.3

This toothpaste can trigger remineralization without adding extra fluoride. It also removes the worry about the toxicity associated with higher quantities of fluoride.

How Does Hydroxyapatite Toothpaste Work?

Hydroxyapatite toothpaste works by providing your teeth with the minerals they need to repair themselves. 

When you brush your teeth with hydroxyapatite toothpaste, it helps replenish the minerals that have been lost due to acid erosion.

Demineralization vs. Remineralization

Tooth demineralization occurs when your teeth lose minerals. The bacteria in your mouth thrive off the sugars in the foods and drinks you consume. They produce acids that wear away at your teeth.

Remineralization is the repair process. Imagine it as re-hardening teeth that have become softened by those acids. Your body works to repair the enamel on the tooth surface and prevents mineral loss.

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8 Benefits of Hydroxyapatite Toothpaste

The hydroxyapatite in toothpaste is a synthetic form of the same substance.

Hydroxyapatite toothpaste has several advantages:

1. Food Residue Removal

Like with any toothpaste, hydroxyapatite toothpaste allows you to physically sweep away the residue of food and bacteria lingering in your mouth.

2. Antibacterial Properties

Bacteria in the mouth can lead to tooth decay. They consume traces of the foods and drinks that linger in your mouth when you do not brush your teeth after a meal. As a result, they produce acids that can start dissolving tooth enamel, making them susceptible to cavities. 

A 2017 in vitro study demonstrated that hydroxyapatite toothpaste creates a shield against bacteria.1 This makes your teeth more resistant to dental plaque. 

Plus, the toothpaste helps fill in those small cracks or fissures that occur in your teeth during tooth demineralization, so the bacteria cannot move down into your teeth.

3. Decreased Tooth sensitivity

If you experience tooth sensitivity, hydroxyapatite toothpaste may help your teeth feel less sensitive as it strengthens your enamel.

4. Non-Toxic and Biocompatible

One of the biggest cons of fluoride toothpaste is that fluoride, in high doses, is a neurotoxicant. This means it is a toxin that affects the brain. Fluoride is also a controversial topic for many people.

Hydroxyapatite toothpaste is biocompatible. Your body recognizes it as a substance that belongs there.

The CDC discovered that most kids use more toothpaste than they should.5 This is a significant issue regarding toothpaste, which has hundreds of times more fluoride than that found in water.

5. Whitens Teeth

One of the benefits of using hydroxyapatite toothpaste is an increased whitening effect.

While HAp does not adjust the polishing activity of the toothpaste, it incorporates a whitening element not otherwise found in standard toothpaste.6

6. Good for the Oral Microbiome

Hydroxyapatite toothpaste helps defend your teeth from acid attacks by bacteria without adversely affecting your oral microbiome.

On the other hand, fluoride is bactericidal, killing bacteria in the mouth. Many oral care brands think that by removing bacteria, they are improving the mouth’s health.

However, the oral microbiome requires a decent balance of bacteria to function well and keep your mouth healthy. Agents like chlorhexidine, triclosan, or alcohol may temporarily reduce bacterial overgrowth issues, but they can lead to other health problems over time.

Hydroxyapatite toothpaste prevents acid attacks and won’t destroy your oral microbiome.

7. Resistant to Acidic PH

The mouth’s PH should always be slightly alkaline to prevent inflammation and oral disease. 

Hydroxyapatite toothpaste helps teeth become more resistant to acidic pH in the mouth, which would otherwise break down enamel faster.

8. May Improve Gum Health

Using HAp toothpaste may help improve and strengthen gum and dental health in patients with gum disease. Improvements include dental plaque control, pocket depth, and bleeding gums.

What are the Side Effects of Hydroxyapatite Toothpaste?

There may be rare circumstances of someone experiencing an allergic reaction to hydroxyapatite toothpaste. However, there is no evidence to suggest a likelihood of experiencing any side effects from hydroxyapatite toothpaste.

A 2019 study demonstrated that toothpaste with hydroxyapatite is unlikely to irritate your teeth and mouth. It does not seem to pose any safety concerns.4

Other Forms of Hydroxyapatite

Hydroxyapatite is a mineral found in the human body and is a main component of tooth enamel. It is also used in many forms as a dental product to help strengthen teeth and prevent cavities.

While hydroxyapatite toothpaste is one of the most popular forms of this mineral, there are other ways to get its benefits. Other forms of hydroxyapatite include:

  • Hydroxyapatite mouthwash: This form of hydroxyapatite is a liquid that can be swished around the mouth for up to 30 seconds and then spat out. 
  • Hydroxyapatite gel: This form of hydroxyapatite is applied directly to the teeth with a brush or applicator. 
  • Hydroxyapatite dentifrice: This form of hydroxyapatite is a paste or powder that can be used like toothpaste.

Other Ways to Remineralize Teeth

Demineralized teeth can be a major problem, leading to cavities and other dental issues. 

Using hydroxyapatite toothpaste is one of the most popular ways to remineralize teeth. Aside from this method, you can also try the following:

Maintain Good Oral Health

The best way to remineralize teeth is to maintain good oral health. This means brushing your teeth twice daily, flossing once a day, and using an antibacterial mouthwash. Additionally, you should visit your dentist regularly for checkups and cleanings.

Increase Calcium Intake

Calcium is essential for remineralizing teeth, so it’s important to ensure you get enough of it in your diet. Dairy products, leafy greens, and nuts are all good sources of calcium. You can also take a calcium supplement if needed.

Avoid Sugary and Acidic Food 

Sugar and acid are two of the main culprits for demineralizing teeth. This includes candy, soda, and citrus fruits. You should avoid them as much as possible to maintain teeth that are strong and healthy.

Use Fluoride Treatments

Fluoride is another important mineral for remineralizing teeth. You can get fluoride treatments at your dentist’s office. You can also use fluoridated toothpaste or mouthwash.

Use Xylitol

Xylitol is a natural sugar substitute in many fruits and vegetables. You can find xylitol in many sugar-free products, such as gum. One study showed that chewing xylitol gum can help remineralize teeth.9

Risks of Demineralized Teeth

Demineralized teeth are a common problem that can lead to tooth decay and cavities. Demineralization occurs when the enamel of the teeth is weakened due to acid erosion.

Several factors, such as poor oral hygiene, acidic foods and drinks, and certain medical conditions, can cause it. If you have demineralized teeth, you must take extra care to protect them from further damage.

Common risks of demineralized teeth include:

  • Increased risk of cavities — Demineralized teeth are more prone to decay and cavities due to weakened enamel.
  • Sensitivity — Demineralized teeth can be sensitive to hot and cold temperatures and sweet and acidic foods.
  • Discoloration — Due to the exposed underlying dentin, demineralized teeth can look more discolored or stained.
  • Tooth loss — Demineralized teeth can become brittle and weak, leading to tooth loss.


Hydroxyapatite toothpaste is a popular way to remineralize teeth and prevent cavities. It works by replacing minerals that have been lost due to acid erosion. 

Using hydroxyapatite toothpaste will help you achieve strong, healthy teeth. However, you should still take other steps to maintain good oral health.

Fresher breath, healthier gums, stronger teeth – find it all in 2024's best mouthwashes. Explore the top picks here.

Last updated on February 22, 2024
9 Sources Cited
Last updated on February 22, 2024
All NewMouth content is medically reviewed and fact-checked by a licensed dentist or orthodontist to ensure the information is factual, current, and relevant.

We have strict sourcing guidelines and only cite from current scientific research, such as scholarly articles, dentistry textbooks, government agencies, and medical journals. This also includes information provided by the American Dental Association (ADA), the American Association of Orthodontics (AAO), and the American Academy of Pediatrics (AAP).
  1. Ebadifar, A, et al. “Effect of nano-hydroxyapatite toothpaste on microhardness of artificial carious lesions created on extracted teeth.” Journal of dental research, dental clinics, 2017.
  2. Nath, S. Addition of Hydroxyapatite to Toothpaste and Its Effect to Dentin Remineralization. Korean Journal of Material Research, 2013.
  3. Amaechi, BT, AbdulAzees, PA, Alshareif, DO, et al. Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children. BDJ Open 5, 2019.
  4. Coelho, CC, Grenho, L, Gomes, PS, et al. Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment. Sci Rep 9, 2019.
  5. Thornton-Evans, G, et al. “Use of Toothpaste and Toothbrushing Patterns Among Children and Adolescents – United States, 2013-2016.” MMWR. Morbidity and mortality weekly report, 2019.
  6. Niwa, M et al. “Polishing and whitening properties of toothpaste containing hydroxyapatite.” Journal of materials science. Materials in medicine, 2001.
  7. Meyer, F, et al. “Overview of Calcium Phosphates used in Biomimetic Oral Care.” The open dentistry journal, 2018.
  8. Abou Neel, EA, Aljabo, A, Strange, A, et al. “Demineralization-remineralization dynamics in teeth and bone.” Int J Nanomedicine, 2016.
  9. Thaweboon, S., et al. “Remineralization of enamel subsurface lesions by xylitol chewing gum containing funoran and calcium hydrogenphosphate.” The Southeast Asian journal of tropical medicine and public health, 2009.
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