Updated on August 27, 2025
6 min read

Best Hydroxyapatite Toothpaste Brands

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You might have heard that hydroxyapatite toothpaste is a great fluoride-free solution for tooth sensitivity or enamel strengthening. But can it actually repair microscopic damage to your teeth?

In this article, we’ll discuss everything you need to know about hydroxyapatite toothpaste. This includes what it is, how to use it, and what the best ones are.

How Does Hydroxyapatite Toothpaste Work?

Hydroxyapatite toothpaste mimics the natural mineral that makes up most of your tooth enamel. Hydroxyapatite toothpaste helps repair this damage by filling these microscopic pores and rebuilding enamel structure.

Research shows hydroxyapatite toothpaste performs similarly to fluoride to prevent cavities and may even surpass fluoride in relieving sensitivity. Notable studies include:

  • Orthodontic patients: A six-month trial found 10% micro-hydroxyapatite toothpaste comparable to fluoride paste for cavity prevention.
  • Young children: A one-year study showed hydroxyapatite paste was as effective as fluoride toothpaste in reducing new cavities.
  • Japanese studies: Early trials demonstrated significant cavity reduction with 5% hydroxyapatite over three years.
  • Systematic reviews: Recent reviews conclude that hydroxyapatite is effective in preventing cavities and reducing sensitivity, showing results comparable to fluoride in many studies.

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7 Best Hydroxyapatite Toothpastes

We evaluated the most popular HAp toothpastes based on their ingredients, results, and customer feedback. Here are our top picks:er feedback. Here are our top picks:

1. Boka Nano-Hydroxyapatite Toothpaste

Best Overall

Boka Ela Mint Toothpaste

Boka Toothpaste is a flavorful option with all-natural ingredients, making it a great choice for the entire family. There are seven flavors to choose from, including Coco Ginger, Aloe Mint, and Watermelon Mint.

It can relieve tooth sensitivity, whiten teeth, and leave a fresh feeling. However, some people may not like their flavors, and Boka toothpaste can be hard to find in stores.

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2. RiseWell Mineral Toothpaste

Best Vegan

RiseWell Toothpaste

RiseWell Mineral Toothpaste is a clean, natural, cruelty-free option perfect for vegans. The dentist-approved formula doesn’t contain parabens, sulfates, or artificial ingredients. 

Overall, it’s a great choice for health-conscious buyers. It makes your teeth feel stronger, less sensitive, and brightens your smile without irritation.

While it’s a great choice overall, there’s only one flavor, and it’s a lot less foamy than we’re used to.

3. Davids Premium Sensitive + Whitening

Best Whitening

Davids Nano Hydroxyapatite Natural Toothpaste

Davids Premium Toothpaste goes the extra mile to whiten teeth using micro-polishing beads. It has a Relative Dentin Abrasivity (RDA) of 101, an abrasion level that the American Dental Association considers safe and effective for removing plaque and teeth stains.

It reduces tooth sensitivity over time and has a smooth texture with a refreshing flavor. However, the metal tube packaging can be difficult to use.

4. Ollie Hydroxyapatite Toothpaste

Best Cavity-Fighting

Ollie Hydroxyapatite Toothpaste

Ollie is a strong pick for preventing cavities and whitening teeth, but note that it isn’t a fluoride-free option. It combines fluoride, hydroxyapatite, xylitol, and potassium nitrate to protect you against tooth decay, enamel corrosion, and sensitivity. 

Used regularly, it can make your teeth stronger, healthier, and brighter. It’s a great all-in-one formula that has everything you need.

However, some reviewers think it’s too minty, and you can’t buy it in stores. You might have to order it on Amazon.

5. Apagard Premio Toothpaste

Apagard Toothpaste

Apagard Premio Toothpaste has a special formula designed to prevent stains and plaque. It coats your teeth with a protective layer, resisting stains while making you feel more confident about your smile.

The xylitol-rich blend can reduce levels and acid production of cavity-causing bacteria, while the nano-hydroxyapatite strengthens your teeth. After several uses, it reduces tooth sensitivity and makes your teeth feel stronger and healthier.

It doesn’t have an unusual taste either. But it does have a different mouth feel, and some people might not notice any changes after using it.

6. Dr. Brite Extreme Whitening Toothpaste

Dr. Brite hydroxyapatite toothpaste

Dr. Brite uses a 100% natural formula to give you a healthier smile. Its main ingredient is hydroxyapatite, but the toothpaste also contains vitamin C, activated coconut charcoal, and organic coconut oil.

They work together to clean and whiten teeth, promote gum health, prevent bacterial build-up, and strengthen the enamel. After using it for a month, you’ll start to notice brighter teeth.

However, Dr. Brite may have a grittier texture that some people may not like. It also tastes different from other toothpastes.

7. Bite Toothpaste Bits

Best On-The-Go

Bite Toothpaste Bits

Bite is unique because you literally have to bite into its chewable tablets before you can brush your teeth. It’s fun and great for traveling. 

You can tuck the bottle in your purse without worrying about toothpaste leaking into the rest of your stuff. You can even reuse the glass bottles, making them environmentally friendly and sustainable. 

However, you might be surprised by the different taste and texture it offers. It also doesn’t foam up like regular toothpastes.

What Makes a Good Hydroxyapatite Toothpaste?

Not all hydroxyapatite toothpastes are created equal. Particle size and concentration significantly impact their effectiveness. Here’s why particle size matters:

  • Nano-sized particles (<100 nm) — Penetrate deeper into enamel and dentin, maximizing remineralization.
  • Micro-sized particles (>100 nm) — Larger particles mostly stay on the surface, offering less deep protection.
  • Optimal concentration (around 10%) — Provides the best balance between remineralizing power and a pleasant toothpaste texture.

What to Look for in Hydroxyapatite Toothpaste

Look for these features when choosing hydroxyapatite toothpaste:

  • Percentage of hydroxyapatite — Aim for around 5 to 10% nano-hydroxyapatite.
  • pH level — Neutral or slightly alkaline pH (around 7.0 to 7.5) promotes remineralization.
  • RDA (abrasivity) rating — Lower ratings indicate gentler cleaning, which is ideal for sensitive teeth.
  • Additional beneficial ingredients — Xylitol, zinc, and natural ingredients support oral microbiome health.

What to Avoid

Some brands advertise hydroxyapatite but include minimal or less effective formulations. Check labels to avoid:

  • Toothpastes listing hydroxyapatite low in the ingredient list (less than 5% concentration).
  • Formulas with sodium lauryl sulfate or artificial flavors, which may irritate sensitive mouths.

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Hydroxyapatite as a Good Fluoride Alternative

At NewMouth, we recommend HAp because it’s biocompatible with your teeth and safer if swallowed. Since it’s the same mineral that makes up most of your teeth, it’s non-toxic and safe to ingest, unlike fluoride, which can cause fluorosis if ingested in excess.

While both ingredients have the ability to clean, remineralize, and strengthen teeth, hydroxyapatite toothpastes offer other benefits that fluoride is unable to provide. Here’s why HAp is better:

  • Helps smooth out the enamel without needing harsh chemicals like carbamide peroxide and hydrogen peroxide.
  • Balances the pH level in your mouth, preventing acid formation which can damage the enamel.
  • Promotes a healthy oral microbiome and prevents cavities.
  • Reduces tooth sensitivity over time by remineralizing your teeth and filling in the exposed parts of your dentin.

Talk to your dentist before buying hydroxyapatite toothpaste. They can help you determine which brands are better for your teeth.

Is Hydroxyapatite Toothpaste Safe?

Hydroxyapatite is widely recognized as safe for daily dental care, and the EU Scientific Committee on Consumer Safety has concluded it is safe for use in toothpastes at specified concentrations.

Clinical reviews find nano-hydroxyapatite safe even if swallowed in typical amounts. Extensive testing shows no harmful absorption or toxicity concerns for nano-sized particles.

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Last updated on August 27, 2025
8 Sources Cited
Last updated on August 27, 2025
All NewMouth content is medically reviewed and fact-checked by a licensed dentist or orthodontist to ensure the information is factual, current, and relevant.

We have strict sourcing guidelines and only cite from current scientific research, such as scholarly articles, dentistry textbooks, government agencies, and medical journals. This also includes information provided by the American Dental Association (ADA), the American Association of Orthodontics (AAO), and the American Academy of Pediatrics (AAP).
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