Best Denture Cleaners

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Medically Reviewed
by Dr. Lara Coseo
Alyssa Hill
Written by
Alyssa Hill
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Evidence Based
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5 sources cited
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8 Best Denture Cleaners of 2021

It is essential to clean your dentures every day. Not only does it increase your dentures' lifespan and keep them looking natural, but it also helps maintain good oral health. Cleaning your dentures is easy. Some denture cleaners require overnight soaking, while others clean your dentures in 5 minutes or less. 

If you are looking for more of a deep clean, hot water alone will not be enough to clean your dentures. If the spots are not deep, water can help remove discoloration. However, if you want to remove calculus, bacteria, calcium, and deep stains, it is necessary to invest in a denture cleaner. 

Best Denture Cleaner for Calcium & Calculus RemovalSmile Again Denture Cleaner

Best Denture Cleaning Kit iSonic Denture Cleaner

Best Cleaner for Partial Dentures Polident for Partials

Best Denture Cleaner for Quick CleanPolident 3 Minute Denture Cleaner

Best Denture Cleaner PasteFresh’n Brite Denture Cleaning Paste

The most popular types of denture cleaners include:

  • Dissolving denture cleaning tablets
  • Overnight denture cleaners
  • Denture wipes for on-the-go cleaning and moisturizing 
  • Ultrasonic denture cleaners
  • Denture powders for quick cleaning
  • Denture cleansing paste & brushes

To help you choose the best denture cleaner for your needs, our specialists at NewMouth have compiled a list of the most popular brands below.

8 Best Denture Cleaners

smile again denture cleaner

Smile Again Denture Cleaner

Smile Again denture cleaner removes tough stains from full dentures, partial dentures, night guards, and retainers. This cleaner will not harm the denture base, partial denture metal, or soft reline material. 

Smile Again can remove tobacco, tea, fruit, iron, coffee, and plaque stains from dentures and other dental appliances. It is also one of the few leading brands of denture cleansers that claim to remove calculus and calcium from dentures after just a few uses. 

isonic denture cleaner

iSonic Denture Cleaner

The iSonic is a compact ultrasonic denture cleaner that uses sound waves to deeply clean dentures, mouth guards, and retainers.

This cleaner also comes with a white denture cleaning powder, which provides extra cleaning power in just five minutes. It's also the smallest ultrasonic denture/retainer cleaner available today.

Cost: $$$

polident partial denture

Polident for Partials

Polident Partial Denture Cleaner is specially created for partial removable dentures. Partial dentures often require a different type of cleaner since they combine both acrylic and metal in the base denture materials that are adjacent to your natural teeth.

Using this denture cleaner daily will help protect the metal clasps and prevent corrosion. It also removes denture odor, bacteria, and protects your denture from plaque build-up and stains.

Cost: $$$

protech denture cleaner

ProTech Denture Cleaner

ProTech is an excellent cleaner for heavily stained dentures. It is capable of removing tea, coffee, iron, tobacco, and nicotine stains. Unlike most denture cleaners that provide a simple chlorinated wash, ProTech is a professional-grade denture cleaner that leaves your teeth brighter and fresher. 

Cost: $$$

polident 3 minute cleaner

Polident 3 Minute Denture Cleanser

Best Denture Cleaner for Quick Clean

Polident 3 Minute Denture Cleanser is suitable for full/partial dentures, retainers, night guards, and sports mouth guards. This cleaning solution removes odor-causing bacteria, tough stains, and other bacteria from your dentures in just 3 minutes. If you have a busy lifestyle and are looking for a quick solution, these Polident denture cleanser tablets are an excellent option.

Cost: $$

cleanadent cleaning wipes

Cleanadent Cleansing Wipes

Best On-The-Go Denture Cleaner

The Cleanadent Cleansing Wipes are ADA-approved for effectiveness (when used as directed). These wipes are specially formulated to remove food particles, plaque, and denture adhesives. They also clean your palate and gums, while providing extra moisturization for your dentures. Cleanadent wipes are perfect for on-the-go and while traveling. 

Cost: $$

fresh n bite denture cleaning paste

Fresh’n Brite Denture Cleaning Paste

Best Denture Cleaner Paste

Fresh’n Brite Denture Cleaning Paste is ADA-approved for effectiveness (when used as directed). It helps remove stains, plaque, and bacteria from removable dental prostheses. For best results, you should clean your removable dentures twice daily; in the morning, night, or after eating. You can apply Fresh’n Bite to a denture brush or soft toothbrush. 

Cost: $$

efferdent denture cleaner

Efferdent Overnight Denture Cleanser 

Best Overnight Denture Cleaner 

Efferdent Overnight Denture Cleanser is ADA-approved for effectiveness (when used as directed). These mint anti-bacterial denture cleanser tablets are safe for overnight whitening and soaking. This provides a deeper clean and keeps your dentures bright for many years. 

Efferdent denture tablets are safe to use on removable dentures and orthodontic appliances. After your dentures are clean, the solution will change from blue to green. Rinse with warm water before wearing the dentures.

Cost: $

How to Clean Your Dentures 

There are many removable denture cleaners available. The cleaning instructions will vary depending on which one you choose.

However, you should clean your dentures every day. This includes:

  • Brushing your dentures daily with a special toothbrush
  • Soaking your dentures in a special cleanser (overnight or according to instructions)
  • Cleaning your mouth and gums with a toothbrush and mouthwash
  • Regular visits to your dentist

Denture wearers should always avoid:

  • Harsh cleaning materials
  • Stiff-bristled toothbrushes
  • Bleach
  • Abrasive toothpaste.

All of these materials will damage your dentures over time. Also, make sure you rinse your denture after cleaning.

Why You Should Trust Us 

All medical content on this site, including this guide and other product reviews, is written by our team of experienced writers and researchers. All NewMouth writers vet products that are recommended and reviewed in the industry. In cases where this is not possible, our team will:

  • Compare positive and negative reviews on the products
  • Talk to company leaders to ensure their products are safe and effective
  • Look into costs to ensure customers are getting the best quality products at reasonable prices
  • Read research studies to compare the pros and cons of each product

Every piece of content is heavily reviewed before publication. All content on NewMouth is also medically reviewed by a licensed dentist, specifically any content where we recommend products. Our dentists are specifically instructed to flag any recommendations they don’t agree with. Any products that don’t meet their professional standards are removed.

Many of the products we recommend have the American Dental Association (ADA) Seal of Acceptance. These products are proven to be effective in preventing gum disease, cavities, and other oral health conditions.

When we recommend products that do not include this seal of acceptance, we conduct further research to ensure reputability. This may include speaking with company leaders, reading hundreds of customer reviews, and ensuring they provide quality customer service.


“Cleanadent Paste.” The ADA Seal of Acceptance. MouthHealthy,

Cruz, P., Andrade, I., Peracini, A., Souza-Gugelmin, M., Silva-Lovato, C., De Souza, R., & Paranhos, H. (2011). The effectiveness of chemical denture cleansers and ultrasonic device in biofilm removal from complete dentures. Retrieved August 21, 2020, from

“Efferdent Overnight Denture Cleanser.” The ADA Seal of Acceptance. MouthHealthy,

“Efferdent Denture Cleanser.” The ADA Seal of Acceptance. MouthHealthy,

“Fresh'n Brite Denture Cleaning Paste.” The ADA Seal of Acceptance. MouthHealthy,,%2C%20when%20used%20as%20directed.%22

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