Updated on February 7, 2024
7 min read

Which Brands of Dry Mouth Spray Are Most Effective?

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What is Dry Mouth Spray?

Dry mouth sprays (saliva substitutes) relieve the symptoms of dry mouth (xerostomia).1 They incorporate soothing ingredients that can stimulate saliva production.

The spray coats the oral cavity and helps you in:

  • Chewing 
  • Swallowing
  • Speaking
  • Digesting  

It can also rinse away bacteria and protect teeth from cavities. Most sprays are portable and convenient.

How Do Dry Mouth Sprays Work?

Dry mouth sprays coat the oral cavity with a moisturizing agent. You can quickly moisten your mouth with one or two spurts.

Most sprays contain one of the following ingredients: 

  • Carboxymethylcellulose — Reduces the symptoms of dry mouth by lubricating the oral cavity2 
  • Glycerin — Coats your tongue, teeth, and gums to retain moisture 
  • Xylitol — Protects your teeth against bacteria and decay3

While this product can’t wholly replace normal saliva production, it helps lubricate your tongue, cheeks, gums, and teeth. It can provide dry mouth symptom relief.

This moisturizing mouth spray typically contains a mild mint flavor to make the experience more pleasant. They’re also often alcohol-free to avoid drying out your mouth.

Are Dry Mouth Sprays Safe and Effective?

Dry mouth sprays are safe and effective. You should avoid using them if you are allergic to any ingredient(s).

It’s best to consult your dentist if you’re considering purchasing this mouth spray. Discuss your needs with your primary healthcare provider to avoid medication interactions.

Studies on Using a Moisturizing Mouth Spray

Several studies have shown the effectiveness of dry mouth sprays in providing dry mouth symptom relief. 

  • Certain dry mouth sprays are more effective than others9
  • Nearly half of the participants found the dry mouth spray’s taste pleasant10 
  • Dry mouth sprays will not treat the underlying causes of xerostomia11 
  • They’re an effective portable treatment that you can use multiple times daily

While these mouth sprays aren’t a cure or long-term solution, they can immediately relieve xerostomia symptoms.

Can Dry Mouth Sprays Be Used Daily?

You can use dry mouth spray daily as directed by the manufacturer. You can also use the spray to moisten your mouth before bed.

Multiple applications throughout the day are safe. However, do not exceed the recommended dose. 

Best Dry Mouth Sprays for Immediate Relief

Below are the top dry mouth spray brands, several of which you can find at your local drugstore or retail center:

Lubricity Dry Mouth Oral SprayEssential Sprays Dry Mouth SprayMouthKote Dry Mouth SprayBiotene Moisturizing Spray Pro-Sys Alcohol-Free Dry Mouth Spray
Cost $19.954$24.995$9.256Varies by retailer7$10.498
Amount 2 fluid ounces2 fluid ounces2 fluid ounces1.5 fluid ounces 2 fluid ounces
Ingredients Water, xylitol, sodium hyaluronate, sodium benzoate, potassium sorbateWater, Aloe Barbadensis Leaf Juice, Glycerin, Xylitol, Cocos Nucifera (Coconut) Oil, Mentha Piperita (Peppermint) Oil, Cannabis Sativa (Hemp) Seed Oil., Mentha Arvensis (Menthol), Calcium Ascorbate, Mentha Spicata (Spearmint) OilWater, xylitol, sorbitol, Yerba Santa, citric acid, natural lemon-lime flavor, ascorbic acid, sodium benzoate, sodium saccharinPurified Water, Glycerin, Xylitol, PEG-60, Hydrogenated Castor Oil, VP/VA Copolymer, Flavor, Sodium Benzoate, Xanthan Gum, Methylparaben, Propylparaben, Sodium Saccharin, Cetylpyridinium ChlorideDeionized water, xylitol, glycerin, pluronic, xantham gum, flavor, dimethicone, sodium benzoate, sodium saccharin, EDTA 
Flavor Flavorless Fresh mint Lemon-lime Mild mint Mild mint
Longevity Lasts up to 4 hours Information unavailableLasts for up to 1 hour and 55 minutes Lasts up to 4 hours Information unavailable 
Sugar content Sugar-free Sugar-free Sugar-free Sugar-free Sugar-free 

Sugar-free dry mouth sprays help reduce the amount of sugar that sits on your teeth. Look for dry mouth sprays with zero sugar to help maintain your oral health.

How to Use Dry Mouth Sprays

Here are the basic steps involved in using a moisturizing mouth spray: 

  1. Wash your hands and rinse your mouth
  2. Read the manufacturer’s instructions on priming the spray; you may need to shake or turn the bottle upside down 
  3. Turn the nozzle toward you, close to your lips 
  4. Open your mouth and depress the nozzle to apply the moisturizing mouth spray
  5. Avoid spraying directly at the back of your throat 
  6. Don’t swallow immediately, but use your tongue to distribute the product 
  7. Reapply the spray as often as directed on the manufacturer’s packaging

Store your spray at room temperature, away from children and pets. Don’t use it if it’s expired; only take the recommended dose per the manufacturer’s label.

Factors to Consider When Purchasing Dry Mouth Spray

With so many dry mouth sprays available, finding the right one can be challenging. Here’s a list of factors to help you decide which dry mouth spray works best for you.


Most dry mouth sprays cost under $30, but that doesn’t mean they’re a small investment. Depending on how often you use dry mouth spray, you may often need a new bottle, which can increase your costs.

Purchasing a more affordable spray may not offer the best results. So, deciding on the cost can be a balancing act. 


Natural dry mouth sprays often prioritize a short list of clean ingredients. If you are allergic to certain ingredients, avoid using sprays that contain them. Many contain xylitol instead of sugar to remain sugar-free.

Ease of Use

The best dry mouth sprays should be easy to use. Depressing the plunger should take little force, and the spray pattern should cover your mouth.

Dry mouth sprays may come with a replaceable cap that protects the nozzle when not in use. Look for a dry mouth spray that doesn’t leak between uses. 


Most dry mouth sprays can be used multiple times daily, but constantly applying the spray can easily use up the product. Some sprays allow you to go hours between uses, which is convenient. These sprays can also last longer because you don’t need to use so much product.

Tips for Selecting the Best Dry Mouth Spray

Often, the deciding factor between dry mouth sprays is personal preference. Here are a few tips to consider when selecting one for you: 

  • Look for a mouth spray that’s alcohol-free and contains no artificial sweeteners 
  • For sensitive teeth and gums, look for a moisturizing mouth spray specifically formulated for your needs
  • Search for a mouth spray that contains a pH balance to support natural and healthy bacteria in your mouth
  • Select a moisturizing mouth spray based on longevity, ease of use, and taste 
  • Continue your oral care routine as directed by your dentist while using the mouth spray 

You should also consider purchasing a moisturizing mouth spray with the ADA Seal of Acceptance.12 These products have been shown to combat xerostomia symptoms effectively. 

What Users Are Saying About Dry Mouth Sprays

Many people struggle with dry mouth but find dry mouth sprays affordable, effective, and convenient. The application requires little effort, and most sprays allow for several applications within a 24-hour period.

Brands typically offer mild flavors such as mint to avoid a chemical aftertaste. Dry mouth sprays are also discreet and portable, small enough to travel with you through the airport if necessary.

However, some users only found temporary relief with a dry mouth spray. Others reacted adversely to many brands’ flavors, citing them as overwhelming.

A few people also noticed that the spray left a sticky residue in their mouths. Users focused on natural ingredients struggled to find brands offering this product.

What are the Side Effects of Moisturizing Mouth Sprays?

Some dry mouth sprays contain sodium, which can negatively impact your health if you’re on a salt-restricted diet. You may also experience a change in speech with the additional lubricity provided by the dry mouth spray.

If you are allergic to one or more ingredients, you may experience: 

  • Swelling of the face, lips, tongue, or throat
  • Tightness in your chest or throat
  • Hives or a skin rash
  • Itching 

If you experience these symptoms, stop using the mouth spray and seek medical attention immediately.


Dry mouth sprays are a common, over-the-counter solution for symptoms of xerostomia. These sprays can help relieve dry mouth with several applications throughout the day.

Speak to your dentist or doctor about adding dry mouth spray to your oral care routine. In addition to proper brushing habits, a dry mouth spray can support a healthy mouth.

Last updated on February 7, 2024
12 Sources Cited
Last updated on February 7, 2024
All NewMouth content is medically reviewed and fact-checked by a licensed dentist or orthodontist to ensure the information is factual, current, and relevant.

We have strict sourcing guidelines and only cite from current scientific research, such as scholarly articles, dentistry textbooks, government agencies, and medical journals. This also includes information provided by the American Dental Association (ADA), the American Association of Orthodontics (AAO), and the American Academy of Pediatrics (AAP).
  1. Xerostomia (Dry Mouth).” American Dental Association, 2023.   
  2. Oh et al. “Effects of carboxymethylcellulose (CMC)-based artificial saliva in patients with xerostomia.” International Journal of Oral & Maxillofacial Surgery, 2008.
  3. Dry Mouth.” The American Academy of Oral Medicine, 2023. 
  4. ​Lubricity Dry Mouth Oral Spray Full Size.” Lubricity Innovations, 2023. 
  5. Essential Sprays All-Natural Dry Mouth Spray.” Essential Sprays, 2023. 
  6. Mouth Kote® Dry Mouth Spray.” Parnell Pharmaceuticals, 2023. 
  7. Biotène Moisturizing Mouth Spray.” Haleon, 2023. 
  8. https://www.pro-sys.com/product/dry-mouth-spray/.” Benco Dental, 2023. 
  9. Shirodaria et al. “Subjective assessment of a new moisturizing mouth spray for the symptomatic relief of dry mouth.” The Journal of Clinical Dentistry, 2006. 
  10. Silvestre et al. “Clinical evaluation of a new artificial saliva in spray form for patients with dry mouth.” Medicina oral, patologia oral y cirugia bucal, 2009. 
  11. Dry Mouth.” MouthHealthy, 2023.  
  12. Accepted Products.” American Dental Association, 2023.
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